Will Telomerase Become an Anti-Aging Mechanism?

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Essay #: 073137
Total text length is 6,695 characters (approximately 4.6 pages).

Excerpts from the Paper

The beginning:
WILL TELOMERASE BECOME AN ANTI-AGING MECHANISM?
Telomerase is the
ribonucleocprotein
enzyme that determines telomere length (Harley, 1991). Diminishing telomere length was hypothesized to lead to slowed cell growth and eventual cell death. Telomerase activity does not appear in normally functioning somatic cells, only in single-cell immortal eukaryotes (Harley, 1991). It is hypothesized that telomeres, which are at the ends of chromosomes, may shorten with each cell replication. When cells reach maximum growth, they enter what is called
replicative
senescence (
Bodner
, et al., 1998). Cellular senescence is the point at which a cell ceases to divide. Telomere shortening and senescent cells have been directly linked with aging and...
The end:
.....ssible manipulation of telomere cells to slow the aging process and perhaps mitigate age-related diseases.
References
Bernardes
de Jesus, B.,
Blasco
, M.A. (8 Jan 2011). Aging by telomere loss can be reversed. Cell Stem Cell. 8(1):3-4. Retrieved 8 Dec 2011 from http://www.ncbi.nlm.nih.gov/pubmed/21211774
Bodnar
, A.G., Ouellette, M.,
Frolkis
, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W.,
Lichtsteiner
, S., and Wright, W.E. (Jan 1998). Extension of life span by introduction of telomerase into normal human cells. Science, 279,(5349), pp. 349-352. Retrieved 8 Dec 2011 from http://www.jstor.org/stable/2894563
Harley, C.B. (23 Jul 1991). Telomere loss: Mitotic clock or genetic time bomb? Mutation Research, 256, pp. 271-282.