Vascular Physiology of Atherosclerosis Introduction Atherosclerosis is the leading cause of death globally and researchers agree that the traditional focus on major systemic risk factors is not sufficient to explain the nature of this disease. Over the past decade, endothelial function has been expanded to include regulation of inflammation in vessel walls as well as thrombotic and thrombolytic factors. Major systemic atherosclerotic risk factors are incapable of encompassing the focal and eccentric location of various lesions which is why shear stress is identified as the dominant variable that explains localized eccentric plaque distribution while also playing a role in normal lumen preservation ( Kinlay & Libby, 2001; Slager...The end:
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