High Dose Steroids in the Early Management of Spinal Cord Injury


Add to cart
Essay #: 060787
Total text length is 16,147 characters (approximately 11.1 pages).

Excerpts from the Paper

The beginning:
High Dose Steroids in the Early Management of Spinal Cord Injury
Spinal cord injury is a major cause of disability in Canada and the rest of the world. It is particularly devastating since the resulting disability affects young people in their prime of their lives. Early management of this condition reduces the extent and severity of permanent damage and disability from spinal cord injuries. The use of steroids in the early management of spinal cord injury is associated with much controversy. The history of steroid use has led to the development of this controversy. According to Galandiuk et al., (1993, p424) the acceptance of this practice by the medical community occurred after a May, 1990 publication of a clinical trial...
The end:
.....the treatment of acute spinal-cord injury: results of the second National Acute Spinal Cord Injury Study. New England Journal of Medicine 322,1405-1411.
Lee, J., Yan, P., Xiao, Q., Chen, S., Lee, K., Hsu, C.Y. and Xu, J. (2008) Methylprednisolone protects oligodendrocytes but not neurons following spinal cord injury. Neuroscience. 28(12): 3141–3149. doi:10.1523/JNEUROSCI.5547-07.2008.
Galandiuk, S., Raque, G., Appel, S. and Polk ,H.C. (1993). The two-edged sword of large-dose steroids for spinal cord trauma. Annals of Surgery. 218(4):419-25
Xu, J. Chen, I., Chen, H., Xiao, Q., Hsu, C.Y., Michael, D., and Bao, J. (2009). STAT5 Mediates Antiapoptotic Effects of Methylprednisolone on Oligodendrocytes Journal of. Neuroscience. 29(7): 2022–2026.