Drug-Receptor Interaction for Histamine Receptor H1

Excerpts from the Paper

Drug-Receptor Interaction for Histamine Receptor H1
Since the value of histamine was discovered in regards to allergic conditions there has been numerous studies to develop drugs that trigger histamine action in the body. In 1933 it was discovered that Histamine H1 receptor hampered studies due to the effects of sleepiness from the sedative. A second generation of H1 was developed and it was a non-sedative receptor. The drugs associated with the second generation of H1 are
astemizole
,
acrivastine
,
cetirizine
,
loratidine
, and
terfenadine
(Wieland 1999).
Histamine is produced in the lungs, skin and gastrointestinal tract naturally. Histamine is stored in cells and in the
basophils
. Histamine is in granule form in cells and held there by...

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Ter
Laak
, A.,
Smit
, M.,
Kuhne
, R., Timmerman, H.
and
Leurs
, R 1999, ‘Mutational Analysis of the Antagonist-binding Site of the Histamine H1 Receptor’, Journal of Biological Chemistry, Vol. 274, Mo. 42. <http://www.jbc.org/cgi/content/full/274/42/29994>.