DNA Damage in Pharmacology and Toxicology


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Essay #: 072925
Total text length is 10,758 characters (approximately 7.4 pages).

Excerpts from the Paper

The beginning:
DNA Damage in Pharmacology and Toxicology
Review of a research paper arguing that oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication
The following paper looks at an article entitled, “Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication.” This paper addresses a number of issues in assessing the article: what was the current state of knowledge prior to the release of the paper? What did the paper describe; how was the work performed; and what was the conclusion of the paper? What impact – or lack of impact – did the paper have upon the field of study; in other words, how did this paper contribute to the present-day state of knowledge or body of knowledge available to...
The end:
Seminars in Cancer Biology, 20.5(2010): 281-293.
, Hideki Harada, T.B.
, Kenji
, C.D.
, et al. “Ha-RasG12V induces senescence in primary and immortalized human esophageal keratinocytes with p53 dysfunction.” Oncogene, 23(2004): 6760-6768.
Watanabe, Yoshihisa, & Masato
“Spatiotemporal Regulation of DNA Replication in the Human Genome and its Association with Genomic Instability and Disease.”
Current Medicinal Chemistry, 17.3(2010): 222-233
Zhu, W., C.Y. Lee, R.L. Johnson, J.
, R. Huang et al. “An image-based, high-throughput screening assay for molecules that induce excess DNA replication in human cancer cells.” Molecular Cancer Research: MCR [
Cancer Res] 9(3): 294-310.